PRE-FORMULATION STUDY ON 5-FLUOROURACIL AND CERTAIN LIPIDS FOR SOLID LIPID NANOPARTICLES PREPARATION

Objective: The study's objective involved compatibility studies to investigate the possible interactions between 5-fluorouracil (5-FU) and four different lipids, most appropriate lipid was chosen. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FT-IR) are used for study 5-FU several excipients as cholesterol, compritol®, stearic acid, glycerol monostearate (GMS). Methods: physical mixture each made by mixing of a certain amount drug with same lipid. Drug blended mixtures were solvent evaporation casting method. alone, measured using (DSC) melting peak effect on this point, (XRD) observe crystalline or amorphous state determine any chemical interaction these lipids observing shift happened characteristic peaks related drug. Results: Tm (280.04 °C) appeared in drug-lipid minor changes position while disappeared 5-FU-compritol® 5-FU-cholesterol mixture, indicating that is molecular dispersed. XRD result showed structure present disappeared, confirming DSC result. FT-IR spectrum 5-FU-physical all changes. In case 5-FU-blended mentioned no occurred except drug-stearic acid N-H at 3136.25 cm-1 due amide ester formation. Conclusion: suitable preparation solid nanoparticles GMS cholesterol.